AFP and hepatocellular carcinoma: A meta-analysis study comparing the accuracy of ultrasound with or without AFP for HCC surveillance found that ultrasound with AFP had a significantly higher sensitivity than ultrasound alone, with the pooled sensitivity of 63% (95%CI, 48–75%) and 45% (95%CI, 30–62%) for early-stage HCC, respectively (p = 0.002), which suggests that, among currently available tests, ultrasound in combination with AFP may be the most effective strategy for HCC surveillance in patients with cirrhosis [10,23].