Notably, immunization with the A-G-eGN and G-eGN vaccine was capable of eliciting higher numbers of IFN-γ and IL-4 SFCs and level of cytokines compared with the numbers observed for A-G-eGC, G-eGC, A-G-NAb and G-NAb vaccinated mice (Figure 6A,B), which may be one reason why the mAbs of GN has a better protective effect than those of GC [5], which is worthy of further research. This evidence concerns the gene IL4 and ganglioneuroma.