Members of the FoxO protein family are well-known transcriptional factors that are regulated by the insulin/PI3K/Akt signaling pathway and are known to have many diverse roles in cell cycle progression, apoptosis, metabolism, differentiation, and oxidative stress resistance [50,51,52,53] including roles in viral infections [54,55,56,57,58,59,60,61,62,63,64,65]. This evidence concerns the gene INS and viral infectious disease.