AU-011 mediated tumor cytotoxicity also leads to the release of tumor neoantigens, and damage associated molecular patterns (DAMPs), such as ATP, cell-free DNA, HMGB-1, and the subcellular re-localization of ER proteins HSP70 and calreticulin to the surface of the cell, resulting in a potently immunogenic tumor milieu capable of stimulating cell-mediated anti-tumor immunity (Figure 3) [178]. The gene discussed is HMGB1; the disease is neoplasm.