In a MERS-CoV infection [95], the epithelial and endothelial cells induced significant but delayed IFN and pro-inflammatory cytokine (IL-1β, IL-6 and IL-8) responses, while a large quantity of CCL3, CCL5, CCL2, and CXCL10 was produced during a SARS-CoV infection [96]. This evidence concerns the gene IL6 and severe acute respiratory syndrome.