Recombinant proteins did not induce any protection against helminth infection; however, the immunization with the rSs14-3-3 previous to infection elicited a higher expression of the anti-inflammatory cytokines IL-13, IL-10 and TGF-β associated with a Th2/Treg response in the spleen, which could be involved in promoting the establishment of the parasite and the success of the infection. This evidence concerns the gene TGFB1 and infection.