HLA-C and neoplasm: Whether a gene mutation can generate a new tumour antigen depends on (1) whether the gene mutation sequence is converted into a protein; (2) whether the mutated protein is processed into polypeptides; (3) the affinity between MHC molecules and the mutant peptide; and (4) the binding of TCRs to the mutant peptide-MHC complex [28,29,30].