On the other hand, the hHub-DEGs shared significant KEGG pathways, noticeably Kaposi sarcoma-associated herpesvirus infection, AGE-RAGE signaling pathway in diabetic complications, Human cytomegalovirus infection, Shigellosis, Hepatitis B, Lipid and atherosclerosis, Coronavirus disease-COVID-19, HIF-1 signaling pathway, and pathways in cancer (Figure 3). The gene discussed is RENBP; the disease is shigellosis.