We identified 14 hHubGs (AKT1, APP, CXCL8, EGFR, IL6, INS, JUN, MAPK1, STAT3, TNF, TP53, UBA52, UBC, VEGFA) that were related to COVID-19 in host cells along with 5 TFs (GATA2, FOXC1, TFAP2A, and YY1) as the transcriptional and 5 miRNAs (miR-106a-5p, miR-17-5p, miR-20a-5p, miR-106b-5p, and miR-93-5p) as the post-transcriptional regulators. This evidence concerns the gene MAPK1 and COVID-19.