In the diphtheria toxoid (PDB 1MDT), 5 out of 18 immunodominant B regions (255–260 [64], 381–394 [64], 395–403 [63], 452–458 [64], and 465–475aa [64]) are located next to immunogenic CD4 epitopes (271–290, 351–371, 411–430, 431–450aa [62]), possibly in the ideal position to be boosted upon BCR binding (Figure 1. Here, CD4 is linked to diphtheria.