Similarly, immunodominant CD4 T cell epitopes (401–430aa) [17] largely overlap with neutralizing B cell regions in the influenza HA stem (PDB 5JVR; Figure 4 and Table S6), with 50% essential amino acids for MEDI8852 binding to the HA stem located within the highly immunogenic CD4 T regions (401–430aa) [17]. The gene discussed is CD4; the disease is influenza.