Additionally, Moqidem [18] suggested that cell death induced by A. vulgaris on SH-SY5Y human neuroblastoma cell line was through apoptosis induction accompanied by significant downregulation of the cell cycle genes (CDK4, CDK6 and E2F3), and upregulation of the tumor suppressor gene PTEN. The gene discussed is PTEN; the disease is neuroblastoma.