As reported in a previous study, nanoparticles formed by 2-methoxy-estradiol (2-ME) based on anti-human epidermal growth factor receptor 2 (HER2) antibody-modified BSA were validated in targeted cancer therapy; this system was prepared using the desolution method and was proven effective in retaining the immunospecificity of the anti-HER2 antibody for the targeted cancer therapy [100]. Here, ERBB2 is linked to cancer.