In addition, expression levels of CD11c, an integrin involved in a variety of cell-matrix and cell–cell adhesion functions [93], in monocytes of RA patients treated with ADA was associated with future response [92]; however, no association with response to ADA (p = 0.33) or ETN (p = 0.13) was found in PBMCs from 75 patients [76]. This evidence concerns the gene ADA and rheumatoid arthritis.