In addition, Hu et al. reported hyaluronan-coated albumin NPs for the co-delivery of a hydrophobic natural compound (celastrol) and hydrophilic IDO inhibitor (1-methyltryptophan), achieving effective tumor inhibition in pancreatic cancer mouse models by relieving the immunosuppressive TME [162]. This evidence concerns the gene IDO1 and familial pancreatic carcinoma.