Based on the different acidity characteristics of the tumor extracellular microenvironment (approximately pH 6.5) and lysosomal environment (approximately pH 5.5), dual-pH-responsive micelles were reported to achieve sequential release of two drugs acting on extracellular (anti-PD-1 mAbs to block PD-1 in T cells) and intracellular (Cur to promote the tumor infiltration of T cells by inhibiting NF-κB pathway), respectively [142]. The gene discussed is PDCD1; the disease is neoplasm.