For instance, the decoration of tumor specific targeting ligands such as arginine-glycine-aspartic acid (RGD) peptide [42], folic acid (FA) [43], hyaluronic acid (HA) [44] and transferrin (Tf) [45], can help NPs deliver siRNA to desired organs by specifically recognizing corresponding receptors, and promote the endocytosis of NPs through receptor-mediated endocytosis. The gene discussed is TF; the disease is neoplasm.