Utilizing the αPD-L1 to prepare αPD-L1 Chloringlobulin, they treated orthotopic glioma-bearing mice with a combination of image-guided surgery, PD-L1 and PDT therapy, and fluorescence image-guided PDT combined with a PD-L1 and CTLA-4 dual blockade, which was used to treat colon cancer. This evidence concerns the gene CD274 and central nervous system cancer.