CD274 and melanoma: In order to overcome the light penetration problem in melanoma, Huang et al. used chlorin e6 (Ce6) as both photosensitizer and sonosensitizer to produce ROS and developed a lipid (LP)-based micellar containing both Ce6 and the anti-PD-L1 antibody (PEG-CDM-aPD-L1/Ce6) [56].