TNFRSF10B and posterior cortical atrophy: Gagandeep et al. treated three different human PCa cell lines, 22Rv1, LAPC, and LNCaP, with isosilybin A. Both exogenous apoptotic pathways (increased levels of DR5 and cleavage of caspase 8) and endogenous apoptotic pathways (activation of caspases 9 and 3) were induced, resulting in apoptotic cell death [54].