A recent study reported that the application of ointment containing josamycin (Adipogen, Liestal, Switzerland) to the skin of AD mice attenuated dermatitis, reduced the number of S. aureus by inhibiting S. aureus colonization and Th2 cell differentiation, down-regulated IL-31 expression, and suppressed itch in skin [45]. This evidence concerns the gene IL31 and Alzheimer disease.