In conclusion, the current study reveals for the first time that galangin exhibits neuroprotective effects, as evidenced by the improvement of neuronal viability and behavior in 6-OHDA-treated HT22 cells and C. elegans, by activating the Nrf2/Keap1/HO-1 signaling pathway, which provides novel insight into the further development of galangin as a candidate for the treatment of PD in the future. Here, KEAP1 is linked to Parkinson disease.