The current study investigated the protective influence of phytochemicals supported by PhM against AD progression induced by AlCl3 via exploring their impact on four interconnected axes, namely, Nrf2/HO-1, TLR4/NLRP3, APOE4/LRP1, and Wnt3/β-catenin/GSK-3β pathways that associated with the pathophysiology of AD. Here, NFE2L2 is linked to Alzheimer disease.