Preclinical studies have also shown that glutathione S-transferase alpha 4 (GSTA4-4) inhibitors, sestrins activators, TGFβ receptor 1 inhibitors, and recombinant human neuregulin-1, through several underlying pathogenic mechanisms, preserve cardiac function and late myocardial fibrosis after radiation [120,121,122,123]. Here, GSTA4 is linked to Myocardial fibrosis.