[68Ga]Ga-PSMA-Q exhibited the highest tumor-to-muscle (T/M) ratio (31.44 ± 2.09 at 60 min p.i.), which was higher than those of [68Ga]Ga-PSMA-617 (28.43 ± 0.84, p < 0.05), [68Ga]Ga-PSMA-11 (17.41 ± 1.80, p < 0.05), and all other novel tracers. The gene discussed is FOLH1; the disease is neoplasm.