An increased expression of ABCC 2 to six was observed in relapsed pediatric ALL patients compared to non-relapsed patients, who also showed a decreased expression of ABCC1. It is also interesting to note that ABCC 4 and 6 was higher among those who received high doses of daunorubicin and L-asparaginase [60]. This evidence concerns the gene ABCC1 and acute lymphoblastic leukemia.