ACHE and Alzheimer disease: Taken together, our previous in vitro study, which showed that KBD demonstrates multiple modes of action against the AD pathological cascade including antioxidant, anti-AChE, anti-Aβ-aggregating, neuroprotective, and anti-apoptotic activities [29], and the present study, demonstrate that KBD can improve the short- and long-term memory performance of Aβ-induced AD rats by increasing the activities of the antioxidant enzymes CAT, SOD, and GPx; reducing the MDA content, and; decreasing the acetylcholinesterase activity in the brain.