SIRT-1 deficiency affects transcription factors (p53, PGC-1, NF-B, and FOXO) as well as molecular alterations like gene expression, which influences brain plasticity, Th17 cell suppression, and interleukin-1 production [26,27].SIRT-1 activation via SIRT-1 activators appears to help with mood disorders [28], MS [29], Parkinson’s disease (PD) [30], and Alzheimer’s disease (AD) [18]. Here, TP53 is linked to Alzheimer disease.