IL1B and Arthritis: Arthritis is a chronic disease caused by the dysregulation of pro-inflammatory cytokines (e.g., tumour necrosis factor and interleukin-1beta) and proinflammatory enzymes that mediate the production of prostaglandins (e.g., cyclooxygenase-2) and leukotrienes (e.g., lipoxygenase), along with the expression of adhesion molecules, matrix metalloprotein and hyper-proliferation of synovial fibroblast [76].