AKT1 and pachyonychia congenita: On this basis, the major aims of this research are to determine the function of PC on keratinocyte proliferation and to monitor the expression and activation status of important kinase markers in the MAPK signal transduction pathway (ERK 1/2, pERK1/2) and PI3K/Akt signal transduction pathway (pAkt and Akt) in response to PC treatment.