Cytokines such as TNF-α, Interleukin 1 (IL-1), IL-6, IL-7, IL-15, IL-17, IL-18, IL-21, IL-23, IL-32, IL-33 and granulocyte-macrophage colony stimulating factor (GM-CSF) are important in the development of RA. The gene discussed is IL1B; the disease is rheumatoid arthritis.