To determine whether the AG129 strain, a double-knockout mouse model lacking receptors for both type I (α, β) and type II (γ) interferons (IFNAR−/− IFNGR−/−DKO) is suitable for mosquito vector competence studies analyzing infection and transmission of arboviruses, we first tested mouse survival rates after inoculation with five different arboviruses from two different families: Flaviviridae and Togaviridae (Figure 1). The gene discussed is IFNAR1; the disease is infection.