TLR3 and Zika virus infectious disease: Numerous studies have shown that ZIKV interacts with sensory molecules, such as toll-like receptor 3 (TLR3) and retinoic acid inducible gene 1 (RIG-1) [113], as well as the transcription factors interferon regulatory factor 3 (IRF7) and NFκ-B, following ZIKV infection [71].