The HEP G2 cell line/hepatocyte was the ideal candidate for this study, considering that it exhibits the following characteristics: (1) high permissiveness and overt cytopathology during ZIKV infection (as shown in Figure 3F) [95] and (2) inefficient expression of endogenous IFNε in mammalian cells [106]. Here, IFNE is linked to Zika virus infectious disease.