MMP8 and infective vaginitis: Aggressive vaginal infection by Peptostreptococcus, Streptococcus and Ureaplasma among others might release endotoxin (typically LPS) [5] and induce vaginal epithelia to secrete inflammatory cytokines such as IL-6, and activate matrix metalloproteinases-8 (MMP-8) on the fetal membranes, which results in the breakdown of the extracellular matrix, weakens the fetal membrane, and eventually results in membrane rupture [6].