Longitudinal analysis of the FINRISK97 and Health2000 cohorts of 11 and 7 years shows that IL-1Ra levels increase at baseline with metabolic syndrome (MetS), as compared to metabolically healthy individuals and increasing IL-1Ra levels which independently predict incident T2DM after adjusting for multiple confounders such as BMI, CRP level, and even fasting glucose [28]. This evidence concerns the gene CRP and metabolic syndrome.