A comprehensive MR study that utilized meta-analysis of the associations of MTHFR C677T stroke outcomes confirmed that there was no evidence of benefit for stroke in regions of the world where there was fortification (OR = 0.97, 95% CI, 0.90, 1.11), but there was evidence of potential benefit for stroke in Asia (OR = 0.59, 95% CI, 0.51, 0.69) where there was no folate supplementation [70]. Here, MTHFR is linked to stroke disorder.