TGFB1 and renal cell carcinoma: GSEA analysis identified that the RCC of patients with high PRFT had increased angiogenesis signatures (NES = 1.46, p = 0.04), epithelial-mesenchymal transition (EMT) signatures (NES = 1.53, p = 0.002), and transforming growth factor-β (TGF-β) signatures (NES = 1.42, p = 0.04) (Figure 4C).