PON1 and coronary artery disorder: The lower mean levels of MTHF that were observed in male subjects with CT variants (Table 4 and Table 5), and the higher percentage of subjects who carried QQ of PON1 variants in the subgroups, who also had higher mean MTHF levels than those without R alleles, provide an explanation for the results of an Indian study demonstrating that genotypes of MTHFR C677T CT and PON1 Q192R QQ were significantly associated with the risk of coronary artery disease [28,29].