In both the tumor and spleen of the ApcMin/+ mice, IHS strongly suppressed the expression of IL-5 (p < 0.05; Figure S3A, Supplementary Materials), IL-6 (p < 0.05; Figure S3B, Supplementary Materials), IL-10 (p < 0.05; Figure S3C, Supplementary Materials), P-JAK1 (p < 0.05; Figure S3D, Supplementary Materials), P-JAK2 (p < 0.05; Figure S3E, Supplementary Materials), P-STAT3 (p < 0.05; Figure S3G, Supplementary Materials), and P-STAT5 (p < 0.05; Figure S3H, Supplementary Materials) and enhanced the P-STAT1 expression (p < 0.01; Figure 5A,B; Figure S3F, Supplementary Materials). This evidence concerns the gene IL6 and neoplasm.