Bao, X. et al. designed poly (L-glutamic acid)-graft-methoxy poly (ethylene glycol) containing CA4 (CA4-NPs), and investigated the effectiveness of CA4-NPs together with VEGF/VEGFR2 inhibitor DC101 in improving anti-PD-1 therapy in an H22 tumor model [96]. This evidence concerns the gene CA4 and neoplasm.