activated CD8+ T-cell chemotaxis in the tumor microenvironment via the decreased production of lactate in tumors, the increased IFN-γ production and glucose uptake in CD8+ T cells, and production of CXCL9/CXCL10/CXCL11 in both the tumors and CD8+ T cells. This evidence concerns the gene CXCL9 and neoplasm.