Oxidative stress has a critical position during the progression of NAFLD and hepatic steatosis [59], and the use of exogenous natural antioxidants such as silymarin can trigger various antioxidant enzymes and stimulate non-enzymatic nuclear factor erythroid 2-related factor 2 (Nrf2) pathways, which consequently diminishes oxidative stress [14,51,60]. Here, NFE2L2 is linked to metabolic dysfunction-associated steatotic liver disease.