Interestingly, it was also explored that silybin elevates death receptor 4/5 mRNAs and TNF-related apoptosis-inducing ligand (TRAIL) mRNA expression along with activation of caspase-9, thus indicating a dual mechanism of silymarin inducing potential anti-cancer activity through the augmentation of both the extrinsic and intrinsic apoptotic pathways [131,168]. Here, TNFSF10 is linked to cancer.