The majority of the effects of caffeine are mainly mediated by the blockade of adenosine receptors, and the proved neuroprotective effects of caffeine in brain disorders have been mimicked by the blockade of adenosine A2A receptors (A2ARs) [8,9].The adenosine A2A receptor has been identified as an important and attractive target for nondopaminergic therapy in PD [10,11,12,13,14]. Here, ADORA2A is linked to Parkinson disease.