TGR5 overexpression in the gastric cancer cell line SGC7901 activated by 23(S)-mCDCA greatly inhibited the gene expression of interferon-inducible protein 10 (IP10), TNF-α, and chemoattractant protein-1 (MCP1) induced by NF-κB, as well as LPS. This evidence concerns the gene NFKB1 and gastric cancer.