The activation of TGR5 on the gastric cancer cell line SGC7901 by 23(S)-mCDCA significantly inhibited the downstream gene expression of STAT3, as well as MMP2, complement component 3 (C3), c-Myc, interleukin 6 receptor (IL-6R), epidermal growth factor receptor (EGFR), endothelial PAS domain protein 1 (EPAS), suppressor of cytokine signaling 3 (SOCS3), MMP7, and MMP14 [67]. The gene discussed is STAT3; the disease is gastric cancer.