In HCT116 cells, SW480 cells, and DSS-induced CRC mice, UDCA, as one of the main active components of bile, suppresses the malignant progression of CRC via TGR5 mediating the cAMP-PKA-RhoA signal pathway to antagonize Yes-associated protein (YAP) [72]. Here, GPBAR1 is linked to colorectal carcinoma.