GPBAR1 and breast cancer: Second, in MCF-7 and MDA-MB-231 breast cancer cells, LCA exerted anti-proliferative and pro-apoptotic effects through TGR5 mediating the cAMP-PKA-CREP signal pathway, thereby negatively regulating the gene and protein expressions of P53 and Bcl-2 to suppress the migration and development of breast cancer—suggesting that TGR5 is a novel target for interventions in breast cancer [78].