First, CDCA at low concentrations significantly inhibited Ishikawa cell growth by inducing a remarkable increase in cyclin D1 protein and mRNA expression via TGR5 mediating the ERK-CREB signal pathway, suggesting that CDCA activated the TGR5-dependent CREB signaling pathway to promote human endometrial cancer cell proliferation [77]. Here, CREB1 is linked to endometrial cancer.