GPBAR1 and familial pancreatic carcinoma: Moreover, in pancreatic cancer, TGR5 had a significantly higher expression in the cancerous tissues than the adjacent normal tissues (81.6% vs. 36.8%), and Cox proportional hazards regression analysis confirmed that TGR5 expression was an independent predictor of the overall survival of patients with pancreatic cancer (p = 0.019), suggesting that TGR5 might serve as an important therapeutic target for pancreatic cancer [80] (Figure 7).