They studied the role of DJ12 in breast cancer cell lines MDA-MB-468 and ZR-75, melanoma cell line MDA-MB-435, and pVHL mutant renal cancer cell lines RCC4 and 786-O and concluded that DJ12 not only blocks the binding of HIF-1α to HRE region of DNA but also interferes with its transactivation. This evidence concerns the gene HIF1A and renal carcinoma.