In the cancer cells, HIF-1α not only stimulates the induction of GLUT1, GLUT3 and GLUT4 transporter to uptake blood glucose, but also enhances glycolytic breakdown of intracellular glucose by transactivating phosphofructokinase 1 (PFK1) and aldolase (Figure 2) [52,54,55,56]. Here, PFKM is linked to cancer.