The administration of Aβ1–42 oligomer (4 μg/4 μL; i.c.v.) showed significant (p < 0.05) induction of AD, reflected by brain histopathological changes in hippocampus and cortex region such as neuron loss, neurofibrillary degeneration, neuronophagia, nuclear pyknosis, vacuolation, amyloid deposition, and tau aggregation. The gene discussed is MAPT; the disease is Alzheimer disease.