Resveratrol reduced the expression of heme oxygenase-1 (HO-1) and nuclear factor-E2-related factor 2 (Nrf2), and increased the expression of matrix metalloproteinase (MMP)-2, MMP-9, cyclooxygenase-2, and Toll-like receptor-4 in rats and further inhibited the formation of osteoclasts, the production of inflammation-related proteins, and of circulating ROS in periodontitis rats [83]. This evidence concerns the gene HMOX1 and periodontitis.