Although EGCG alone (5 μM) showed no bioactivity, the flavanone eriodyctiol has been found to potentiate EGCG-induced apoptosis in MM cells (both compounds were used at a concentration of 5 μM), and in a mouse tumor model, by amplifying the activation of the 67LR/Akt/eNOS/PKCδ/ASM pathway elicited by EGCG [9]. Here, SMPD1 is linked to Miyoshi myopathy.