The HF/HS diet-induced adipose tissue increase and triglyceride accumulation in the liver was attenuated by green tea extract/DADS combination, mediated through preventing the upregulation of fatty acid synthesis-related enzymes, such as sterol regulatory element-binding protein-1 (SREBP-1), fatty acid synthase, and stearoyl-CoA desaturase-1. The gene discussed is SREBF1; the disease is hydrops fetalis.