(iii) Tau proteins are misfolded and aggregated in the tauopathies that include AD and FTD; accelerated tau aggregation, apoptosis and neurological dysfunction are induced by a chronic oral administration of aluminum in multiple murine models of tauopathy and induced inflammatory neurodegeneration [51,52,53,54,55,56,57,58,59];. Here, MAPT is linked to Alzheimer disease.