Visual cycle targeting drugs, e.g., Fenretinide, targets RBP4, phase IIβ-Amyloids targeting drugs, e.g., GSK933776, phase I/IIChoriocapillaries atrophy targeting drugs, e.g., Moxaverine, phosphodiesterase inhibitor, phase II/III. This evidence concerns the gene RBP4 and Atrophy.