Moreover, acetylation of high mobility group box-1 (HMGB1) by the JNK1 signaling pathway was observed to be able to promote lipopolysaccharide induced apoptosis via elevating the expression of Bax and cleaved-caspase 3 in peritoneal mesothelial cells in a peritonitis model [16]. This evidence concerns the gene HMGB1 and peritonitis.