CCNA2 and melanoma: In terms of testing the anticancer activity on human melanoma cells, ε-viniferin blocks the cell cycle of melanoma cells in the S-phase by modulating the key regulators of the cell cycle, i.e., cyclins A, E, D1 and their cyclin–dependent kinases 1 and 2, which are associated with the induction of cell death, including apoptosis and necrosis [87].