Although the role of the pyrin inflammasome in the genesis of the inflammatory response to CDI seems predominant, it has been shown that the pathway of the ATP-P2X7 (adenosine triphosphate—purinergic receptor 2X7) complex, known as an activator of NLRP3, is essential for the inflammatory response itself. This evidence concerns the gene MEFV and clostridium difficile infection.