In fact, HCMV and HHV-6 transcripts have been detected in the skin of SSc patients [15,26], and significantly higher levels of anti-HCMV-UL94 and anti-HHV-6-U94 antibodies were observed in SSc subjects, compared with controls [15,27,28,29,30]. This evidence concerns the gene SNORD94 and systemic sclerosis.