In human pancreatic Miapaca-2 and Panc-1 cells in vitro and murine pancreatic cancer cell (Panc02) in vivo, propofol shows a concentration-dependent (5, 25, 50, 100 μM) inhibition of cell migration, expression of VEGF and HIF-1α, phosphorylation of (ERK), AKT, (CaMK II), and Ca2+ concentration [77]. This evidence concerns the gene VEGFA and familial pancreatic carcinoma.